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1. Julius Peppers vs. Seantrel Henderson – Peppers was quiet on Monday night vs. the Falcons, and he's challenged himself and the defense to make more noise in Buffalo. Henderson is a rookie that could have his hands full against Peppers, the wily veteran.
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2. Bryan Bulaga vs. Mario Williams – The Packers right tackle is having a top season and he'll be facing a Cameron Wake-like challenge in Williams, who's one of the league's sacks leader with 12.
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3. Packers interior linemen vs. Kyle Williams and Marcell Dareus – Williams and Dareus are the equivalent of Ndamukong Suh and Nick Fairley. The Bills defensive tackles are premier run-stuffers but they'll also bring a combined 15 sacks to this Sunday's game. Corey Linsley, Josh Sitton and T.J. Lang have to win in the middle to avoid disruption.
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4. David Bakhtiari vs. Jerry Hughes – Hughes is a speed rusher with 9.5 sacks. Aaron Rodgers' blind side must be secured.
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5. Sam Shields vs. Sammy Watkins – Watkins is the Bills' big-play threat. The Packers must deny big plays and make the Bills drive the ball.
Packers.com's Vic Ketchman identifies the five key matchups to look for in Sunday's Packers-Bills game.
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
Peppers was quiet on Monday night vs. the Falcons, and he's challenged himself and the defense to make more noise in Buffalo. Henderson is a rookie that could have his hands full against Peppers, the wily veteran.

The Packers right tackle is having a top season and he'll be facing a Cameron Wake-like challenge in Williams, who's one of the league's sacks leader with 12.

Williams and Dareus are the equivalent of Ndamukong Suh and Nick Fairley. The Bills defensive tackles are premier run-stuffers but they'll also bring a combined 15 sacks to this Sunday's game. Corey Linsley, Josh Sitton and T.J. Lang have to win in the middle to avoid disruption.

Hughes is a speed rusher with 9.5 sacks. Aaron Rodgers' blind side must be secured.

Watkins is the Bills' big-play threat. The Packers must deny big plays and make the Bills drive the ball.